LOSS AND DECREASE OF GROUP AND TYPE REACTIONS AND THE CHANGE OF VIRULENCE OF ANTIBIOTIC RESISTANT STREPTOCOCCUS PYOGENES

YUKIO YAMAZI; TAMAKO YARITA; YOSHITAMI KIMURA

doi:10.1111/j.1348-0421.1961.tb00199.x

YUKIO YAMAZI, TAMAKO YARITA, YOSHITAMI KIMURA

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1961 Volume 5 Issue 2 Pages 183-191

DOI https://doi.org/10.1111/j.1348-0421.1961.tb00199.x

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Published: 1961 Received: February 20, 1961 Available on J-STAGE: April 18, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: April 18, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : Strains S-43 and T-12, respectively type 6 and 12, group A streptococcus
were serially transferred in the presence of chloramphenicol, penicillin, tetra-
cycline or streptomycin. These strains acquired resistance to each antibiotics.
Loss of type and group reactions was observed in the penicillin-or tetra-
cycline-resistant strains, and in the high level-chloramphenicol-resistant strains.
Both reactions were found in the streptomycin-resistant strains or in a low
level-chloramphenicol-resistant strain.
The relationship between the degree of serological reactivity and virulence
to mice was semi-quantitatively investigated. Virulence of the resistant strains was
apparently lower compared to that of original cultures.
A mutant strain from a type 3, group A streptococcus, lacking in M protein
April, 1961 LOSS AND DECREASE OF GROUP AND TYPE REACTIONS 191
but not in C antigen, was incubated with the type 6-M protein, and the increase
of virulence to mice was observed after the treatment. However, enhancement
of virulence was not observed in a penicillin-resistant strain, which originated
from strain S-43 and lacked in M and C antigens, when treated with M protein
or/and M, C antigens.
Right : Strains S-43 and T-12, respectively type 6 and 12, group A streptococcus were serially transferred in the presence of chloramphenicol, penicillin, tetra-cycline or streptomycin. These strains acquired resistance to each antibiotics.
Loss of type and group reactions was observed in the penicillin-or tetra-cycline-resistant strains, and in the high level-chloramphenicol-resistant strains. Both reactions were found in the streptomycin-resistant strains or in a low level-chloramphenicol-resistant strain.
The relationship between the degree of serological reactivity and virulence to mice was semi-quantitatively investigated. Virulence of the resistant strains was apparently lower compared to that of original cultures.
A mutant strain from a type 3, group A streptococcus, lacking in M protein but not in C antigen, was incubated with the type 6-M protein, and the increase of virulence to mice was observed after the treatment. However, enhancement of virulence was not observed in a penicillin-resistant strain, which originated from strain S-43 and lacked in M and C antigens, when treated with M protein or/and M, C antigens.

Date of correction: April 18, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

Strains S-43 and T-12, respectively type 6 and 12, group A streptococcus were serially transferred in the presence of chloramphenicol, penicillin, tetra-cycline or streptomycin. These strains acquired resistance to each antibiotics.
Loss of type and group reactions was observed in the penicillin-or tetra-cycline-resistant strains, and in the high level-chloramphenicol-resistant strains. Both reactions were found in the streptomycin-resistant strains or in a low level-chloramphenicol-resistant strain.
The relationship between the degree of serological reactivity and virulence to mice was semi-quantitatively investigated. Virulence of the resistant strains was apparently lower compared to that of original cultures.
A mutant strain from a type 3, group A streptococcus, lacking in M protein but not in C antigen, was incubated with the type 6-M protein, and the increase of virulence to mice was observed after the treatment. However, enhancement of virulence was not observed in a penicillin-resistant strain, which originated from strain S-43 and lacked in M and C antigens, when treated with M protein or/and M, C antigens.

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