Alterations of Lipid Metabolism in Mice Injected with Endotoxin
1979 年 23 巻 2 号 p. 71-85
詳細
1979 年 23 巻 2 号 p. 71-85
Some alterations in lipid metabolism in mice were observed by the intraperitoneal injection of endotoxin from Salmonella typhimurium. The content of serum triglyceride increased markedly in poisoned mice 16-24 hr postintoxication. The level of free fatty acid (FFA) in the serum of endotoxin-administered mice decreased in inverse proportion to an increase in the injected dose of endotoxin. The electrophoretic analysis of the serum lipoprotein on cellulose acetate membrane showed that pre β-lipoprotein increased markedly and that FFA fraction in the poisoned mice sera disappeared 18 hr postintoxication. The activity of hormone-sensitive lipase in adipose tissue was elevated appreciably 2 hr after injection, but decreased more significantly after 18 hr than that in fasted control mice. On the other hand, the activity of lipoprotein lipase decreased in the post-heparin serum and adipose tissue 3 hr postintoxication, and decreased significantly after 16 hr. There were no significant differences between changes in the formation of active glycerol (α-GP) and in the activity of α-glycerophosphate dehydrogenase (α-GPDH) in the mice liver with or without administration of endotoxin, and after 16 hr levels of both hepatic α-GP content and α-GPDH activity in poisoned mice showed a tendency to be slightly lower than those in fasted control mice.
