Abstract
The purpose of this study was to evaluate the safety and efficacy of chemoradiation therapy with docetaxel, nedaplatin and fluorouracil (5-FU) for patients older than 80 years with advanced esophageal cancer. Three patients were enrolled and received the combination of docetaxel (30mg/m2 on day 1), nedaplatin (10mg/body on days 1～5), and 5-FU (250mg/m2 on days 1～5) with radiation (50.4 to 60Gy in 1.8 to 2-Gy fractions over 6 weeks). Macroscopic and pathologic examinations after treatment showed no esophageal cancers; therefore complete responses were achieved in all patients, and the overall response rate was 100%. Myelosuppressions with grade 2 leukopenia occurred in 2 patients (66%), and grade 3 leukopenia occurred in 1 patient (33%). This chemoradiation therapy is effective and well tolerated by patients older than 80 years with advanced esophageal cancer.
