基礎科学から医学・医療を見る
薬物代謝の化学反応―シトクロムP450反応を中心として
2013 年 9 巻 1 号 p. 25-30
詳細
2013 年 9 巻 1 号 p. 25-30
Drug metabolism involves chemical reactions modifying pharmaceutical substances. Lipophilic chemical compounds are converted to hydrophilic compounds by enzymes related to drug metabolism. Some drugs are activated after drug metabolism; on the other hand, some xenobiotic compounds become toxic through these enzymes. Cytochrome P450 is an enzyme that plays a major role in drug metabolism. Metabolites produced by cytochrome P450 from one drug are predictable from the viewpoint of chemical reactivity. Novel metabolites from nonylphenol and bisphenol A are discovered considering the ipso-position metabolic reaction of cytochrome P450.
