Abstract
Drug discovery from natural products is often hampered by their intrinsic nature. Namely, extracts of natural sources are usually complex mixtures and laborious purification is eventually required. They sometimes contain non-specific active compounds which may lead to false positive hits. Therefore, much effort has been paid to overcome these difficulties, for example, by developing innovative screening program, establishing a robotic system applicable for a mass screening and/or scrutinizing novel natural sources. Among them, the importance of efficient dereplication is getting higher since the probability of discovering novel bioactive compounds is declining as the number of known compounds increases. This paper summarizes and discusses the dereplication strategies including biological, taxonomic, and chemical methods.
