ナノスケールでのRNA 分子構築

抄録

New methods for designing and constructing nanobio RNA molecules are described and discussed. One of the naturally occurring catalytic RNA called Group I intron has been considered as the highly sophisticated assemblage of physically separable structural units termed “modular units.” The intron's crystal structure and 3D models are well established. On the basis of these studies, artificial RNA and RNP molecules were designed by employing a computer program for 3D molecular modeling of nucleic acids and protein. And the small scale in vitro selection technique was also successfully performed for obtaining new modular RNA units with specific roles in the modified natural RNAs. The future application is highly expected in the field of nanobio RNA science and engineering.