Modulation of Erythrocyte Membrane Mechanical Properties by Posttranslational Modifications

Abstract

Proteins are synthesized by translation of mRNA. Their functions are regulated by posttranslational modifications　such as phosphorylation due to change in their structure as well as the physical and chemical properties.　In this review article, we introduced in our experiences that phosphorylation and de-phosphorylation of erythrocyte　membrane skeletal proteins such as spectrin and protein 4.1 (4.1R) change their interactions with binding partners　with modification of membrane mechanical functions.