Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
総説
中枢セロトニントランスポーターと抗うつ薬
酒井 規雄
著者情報
ジャーナル オープンアクセス

2008 年 33 巻 3 号 p. 94-101

詳細
抄録

Serotonin transporter (SERT), a member of Na+/Cl– - dependent transporter family, is predicted to be a protein with a twelve membrane-spanning structure, which terminates the serotonergic neural transmission by re-uptaking serotonin into pre-synapse. It has been well-known that SERT is a target of antidepressants and abusive drugs. Although the pathogenesis of depression and mechanism underlying antidepressants action remains unclear, recent accumulated evidences have revealed that antidepressants promote the regeneration of neurons, which was damaged by repeated stress and recurrences of depression. In addition, analysis of crystal structure of bacterial leucine transporter, a homologue of mammalian Na+/Cl– - dependent neurotransmitter transporter, provides us a new information concerning the interactions of tricyclic antidepressants with serotonin transporter.

著者関連情報
前の記事 次の記事
feedback
Top