Abstract
Preparation and characterization of the cell membrane-inspired polymer materials, which contain 2-methacryloyloxyethyl phosphorylcholine (MPC) unit, are reviewed. The MPC polymer can provide the biointerface to suppress completely the interactions with proteins and cells. Also, on the surface, the biomolecules are immobilized without significant reduction of the their biological activity. Polymer nanoparticles covered with the biointerface and contained quantum dot (QD) s is prepared as the novel bioimaging devices. The kinetic behavior in cytoplasm of the polymer nanopartcles is discussed. Although this nanoparticles can avoid the nonselective cellular uptake from mammalian cells, when bioactive molecules are immobilized, the nanoparticles can provide the various information about the specific interaction between biomolecules and cells. From these findings, it is concluded that the nanoparticles are candidates for the role of stable and highly sensitive fluorescent bioimaging probes in the fields of nanomedicine. Controlling interactions with cells is receiving considerable importance in biomedical fields, including nanobioengineering and cell and tissue engineering. The biointerface described here are a promising design for revealing a universal platform that integrates polymer chemistry; material science; and engineering, biochemistry, cell biology, and nanofabrication.
