抄録
Dynamics in lipid bilayers such as two dimensional domain formation and lateral molecular transportation are crucial factors in cell membrane reactions. In this review several recent studies about the domain formations and molecular diffusion using supported planar lipid bilayers (SLBs) are introduced. SLBs exist at the interface between solid substrates and aqueous solutions, 1 ∼ 2 nm away from the substrate. The fluidity of the membrane remains while the membrane is still affected by the structure and the physical properties of the substrate surface. Two dimensional domain structures on the lateral order of several micrometers in SLB are affected by the atomic scale structures of the substrate. At the latter half of this review, the method of single molecule tracking free from the restriction of substrate materials is described. Lipid diffusions in SLBs on opaque silicon wafer and high refractive TiO2 substrate were observed in situ and the diffusion coefficients were successfully obtained.
