薬物のナノコーティング（S/O^®）技術を利用した化粧品VIVCOシリーズ

抄録

A new cosmetic series VIVCO was commercialized by utilizing the solid-in-oil (S/O^®) technique for L-ascorbic acid phosphate magnesium salt (vitamin C derivative) and hyaluronic acid. In the S/O^® technique, active ingredients are coated by hydrophobic surfactant molecules and the treatment changes their surface properties from hydrophilic to hydrophobic one. Therefore the coated active component can be dissolved in various types of oils and we can get homogeneous cosmetic oil. As a result, the cosmetic oil containing the surfactant-coating ingredient is effective for enhancing the permeation of active components into the deep region of the skin, because the outer surface of skin is hydrophobic. The S/O^® technique was also found to be useful for stabilizing the ingredients by covering with a surfactant layer.