細胞膜リン脂質のスクランブル機構

抄録

Phospholipids on plasma membranes are asymmetrically distributed between inner and outer leaflets. ATPdependent flippases or aminophospholipid translocases regulate the asymmetry of phospholipids, especially the inner location of phosphatidylserine (PS), while calcium-dependent scramblases disrupt this asymmetry, and as a result of that, PS is exposed on the cell surface. PS exposure is biologically important in clearance of apoptotic cells and platelet clotting. However, it is unknown how PS is exposed on the cell surface. In this talk, I will discuss how PS is exposed on the cell surface.