Abstract
Substrate supported phospholipid bilayers are model systems of the biological membrane that offer possibilities for integration (micro-patterning) and sensitive analyses. We developed hybrid membranes composed of polymerized and fluid bilayers. Since the polymeric bilayer provides a robust framework for incorporating various types of lipid membranes, it can be applied to study the functions of membrane-bound proteins and peptides. Amyloid fibril formation has been studied using micro-patterned supported membrane. Since the hybrid membranes are both stable and functional, they should provide a new avenue for generating robust model systems for the basic study of membrane functions as well as biomedical applications.
