抄録
This article describes new aspects of phosphorylcholine (PC)–containing materials over conventional bio–inert properties. First, the artificial PC receptor revealed that activation dynamics of inflammation biomarker C–reactive protein with PC receptors on plasma membranes depended on alternation in surrounding ionic microenvironments such as calcium increases and pH decreases as observed in sites of inflammation and infection during acute phase. The biomimetic receptor allows us to understand well–organized systematic body responses. Second, an energyindependent translocation across the plasma membranes by amphipathic PC–based polymers was discovered for the first time. A newly established assay for measuring plasma membrane leakage proved no formation of molecularly sized pores that are accessible to protons as the smallest indicator when the amphipathic PC–polymers permeate across the lipid bilayers of plasma membranes. The features may find applications in manipulating cytoplasm with high efficiency and low cytotoxicity.
