特集：生体膜シンポジウム「生体膜模倣微粒子の最先端」
DDSを志向したプロバイオティクス由来細胞外小胞の 基礎的特性の解明
2019 年 44 巻 5 号 p. 228-233
詳細
2019 年 44 巻 5 号 p. 228-233
Extracellular vesicles (EVs) are cell–derived lipid membrane nanoparticles that contain nucleic acids and proteins. Since these messages are delivered to target cells via EVs, the role of EVs in biological response has been widely investigated. Moreover, a particular type of EVs is expected to be utilized as a diagnosis and therapeutic application. Recent studies also demonstrated that the release of EVs is widely conserved among organisms. Probiotics is a live microorganism that confer a health benefit on the host. It has been reported that the EVs from probiotics are released to extracellular space. Moreover, given that the characteristics of probiotic–derived EVs are similar to that of EV–producing mammalian cells, development of drug delivery systems by using EVs has been expected. However, the information about the characteristics of EVs from probiotics is hardly investigated. In this review, we first describe our previous study on exosome–based cancer vaccine. Then, we introduce our recent research on elucidation of characteristics of probiotic–derived EVs.
