The assembly of amyloid β protein (Aβ) on membrane microdomains in presynaptic neuronal membranes is involved in the onset of Alzheimer’s disease. The Aβ– sensitive ganglioside nanocluster (ASIGN) was identified by the surface topography of the lipid bilayers composed of brain–extracted lipids. Our results indicate that the ganglioside clustering is responsible for the Aβ– assemblies on the neuronal membranes.
