Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
特集:膜シンポジウム2022 特集号 招待講演
ペプチドと膜の動的相互作用
二木 史朗
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ジャーナル オープンアクセス

2023 年 48 巻 2 号 p. 60-65

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Induction of curvature in lipid bilayers may lead to increased exposure of hydrophobic membrane core to cell surfaces and the eventual hydrophobic interaction with amphiphilic peptides. Not only physicochemical driving force, the membrane curvature and exposure of the hydrophobic core can be elicited by physiological cellular actions including movement of the cell membrane driven by cytoskeletal F–actin restructuring. This review highlights our findings during our studies on developing curvature–inducing peptides and intracellular IgG delivery peptides.
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