Abstract
Nanoparticle has attracted much attention for diagnostic applications. However, delivery of nanoparticles into targeted sites is often prevent by membrane barriers in living environment, which hampers their translation into clinical practice. Recent studies have revealed that physicochemical property of nanoparticles, including size, shape, and surface chemistry, significantly affect their interaction with biological environment. Therefore, optimization of the physicochemical property is expected to improve their delivery efficiency to targeted sites. In this review, we introduce our research on the precise control of the physicochemical property of photo–functional nanoparticles and its subsequent optimization for overcoming membrane barriers in living environment. Use of mathematical model has been proposed as a promising tool to achieve this aim.
