MEMBRANE
Online ISSN : 1884-6440
Print ISSN : 0385-1036
ISSN-L : 0385-1036
Special Topic : Toward an understanding of biological phenomena in cell membranes
Exploring the Differences in Avian and Mammalian Hearts through the Unique Membrane Structures of Cardiomyocytes: Calcium Concentration Management and Cardiac Resilience
Yoshihiro Ujihara
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2024 Volume 49 Issue 2 Pages 82-86

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Abstract
This review delves into the comparative analysis of avian and mammalian cardiomyocytes, focusing on the role of T–tubule membranes in calcium (Ca2+) concentration management and their significance in fostering resilience to mechanical load. Mammalian cardiomyocytes, equipped with complex T–tubule membranes, facilitate uniform and rapid changes in Ca2+ concentration, essential for maintaining resilience under mechanical stress. In contrast, while lacking T–tubule membranes, avian cardiomyocytes have developed unique mechanisms for rapid Ca2+ adjustments. Although avian and mammalian hearts are similar in macroscopic function and structure, differences at the cellular level, particularly in mechanisms of Ca2+ regulation, provide an insightful perspective on evolutionary adaptation.
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