Abstract
The concept of “precision medicine”, which analyzes genomic information at the individual patient level and utilizes it for treatment, is rapidly expanding. Gene therapy and nucleic acid therapy, which complement and suppress the expression of disease–related genes respectively, are expected to become powerful technologies to meet unmet medical needs. Notably, an RNA vaccine against SARS–CoV–2 has been approved. This historical success now accelerates the innovation of mRNA–based medicine worldwide. In these application, lipid nanoparticles (LNPs) are the key delivery system of mRNA and nucleic acids. In this manuscript, the basic concept and design of the intracellular environment–responsive lipid will be summarized. In parallel, I will introduce our original lipid–like materials (ssPalm: SS–cleavable and pH–activated lipid–like material), and application using these materials.
