Abstract
Past investigations on the synthesis of biocompatible polymer materials indicate three promising ways of approach to the goal. First, antithrombogenic materials are synthesized by controlling the surface properties of the material. This approach is explained in reference to polyetherurethanes surface-grafted with polyoxyethylenes. Secondly, antithrombogenic materials are synthesized by combination of synthetic polymers with biologically active substances. This approach is explained with the examples in which heparin is bound to polyetherurethanes by ionic or covalent bondings with or without spacer chains. Thirdly, biocompatible materials are obtained by the growth of endothelial cells on the surface of the material. This approach is explained by referencing to proteinized materials seeded with endothelial cells. The third approach will be most successful in the future.
