Chromatographic and Membrane Separation of Enantiomers Using Polysaccharide Derivatives

Abstract

Phenylcarbamate derivatives, particularly, tris (3, 5-dimethylphenylcarbamate) s of cellulose (CD-MPC) and amylose (ADMPC) are very effective chiral stationary phases (CSPs) for high-performance liquid chromatography (HPLC) and can resolve many racemates including drugs. These polysaccharide derivatives have a merit that affords a film (membrane), which can preferentially adsorb one of the enantiomers. The CDMPC membrane can be used as a solid-membrane for the enantioselective permeation of racemic oxprenolol. Moreover, CDMPC can be utilized as a chiral moving belt for the continuous and preparative enantioseparation of oxprenolol.