Abstract
Separation methods by chromatography and by use of membranes are useful for the enantiomer preparation respectively. The chiral discrimination in both methods is based on the diastereomeric association between the chiral selector and enantiomers in the separation process. Accordingly chiral selectors used as stationary phases for the chromatography are usually available for the separation by use of the membrane. For example, the membranes containing chiral crown ethers, β-cyclodextrin, poly (amino acid) etc. have good capability of separating enantiomers.
Generally chromatographic method is prefer the separation in a small amount of enantiomer, and membrane systems have potential as a tool for large, continuous, preparative scale enantiomer separation.
