2001 Volume 26 Issue 2 Pages 66-71
Transports of water and gases through cell membranes have conventionally been considered to diffuse across the lipid bilayer. Recently, however, it was reported that water transport was mediated by water channel, aquaporin (AQP). Gas permeation, such as CO2 and NH3, was greatly restricted by the apical membrane in epithelia of the urinary tract or colon crypt, a restriction not explained by diffusion. The reason for this low permeation rate was considered to be the difference in lipid composition of the cell membranes. On the other hand, band 3 and AQP have been suggested as possible gas or CO2 channels. In 1998, several reports indicated that AQP1 enhanced CO2 permeation of cell membranes or might be the CO2 channel, although other study disagreed. Recent studies on gas permeation of the cell membrane mediated by protein or an as yet unspecified channel were reviewed.