古細菌モデル糖脂質の膜特性とそのバイオテクノロジー分野への応用

抄録

Because archaeal lipids are considered to be chemically and physically stable, it is of great interest to utilize these lipids as biotechnological materials. We have developed and proposed modeled archaeal diether-type (phytanyl-chained) glycolipids, a series of 1, 3-di-O-phytanyl-2-O- (β-maltooligoglycosyl) glycerols. This review discusses basic membrane properties of the proposed glycolipids, i.e., membrane-formability, intermembrane interaction, proton permeability, and intramembrane environment; subsequently usefulness of these membranes as reconstitution matrices for energy-conversion membrane proteins by employing such as labile oxygen-evolving photosystem 2. The characteristics of the proposed glycolipids are expected to lead to a new class of artificial membrane matrices for basic science such as glycobiology as well as for biotechnological applications.