Hydrogel Membrane of Crosslinked. Polymer Blend of Polyurethane and Polyvinylpyrroliclone

Abstract

Blend of polyurethane and copolymer of N-vinylpyrrolidone and glycidyl methacrylate was fabricated into film by evaporation of solvent from solution of the polymers on a glass plate or cylinder. The film of the polymer blend was converted into hydrogel membrane by hydration after curing. The water content of the membrane increased linearly, with the content of N-vinylpyrrolidone. The hydrogel membrane was found to have larger strength and elongation than conventional ones such as that of poly (2-hydroxyethyl methacrylate). Further, it was shown to be stable in boiling water. The controlled release of 5-FU and methotrexate through the membrane was investigated. The elution rate was unchanged as long as the drug-saturated solution remained in contact with the membrane. The elution rate was conveniently adjusted by regulating the thickness and water content of the membrane.