Differences in physiological activities associated with plasma membranes between liver and hepatoma cells

with special reference to the control of cell proliferation

Abstract

The cancerous changes of plasma membrane activities were reviewed with special reference to the controlling mechanisms of cell proliferation. The article includes the following chapters in addition to introduction and conclusion. Chapter I. Cancerous changes of enzyme systems forming cyclic nucleotides; (a) adenylate cyclase and (b) guanylate cyclase. Chapter II. Cancerous change of cAMP-dependent protein kinase in plasma membranes. Chapter III. Role of plasma membranes in controlling the intracellular Ca²⁺ concentration, and cancerous changes of the controlling systems. Chapter IV. Cancerous changes of Ca²⁺calmodulin-dependent regulatory systems in plasma membranes; (a) calmodulin, (b) cAMP phosphodiesterase and (c) Ca²⁺, Mg²⁺-ATPase. Chapter V. Cancerous changes of other marker enzymes in plasma membranes; (a) 5'-nucleotidase, (b) alkaline phosphatase, and (c) ATPase.