Abstract
Although 16 years passed after a complete genomic sequence of the 3.6 Mb HLA gene region having lots of medical and biological interests was determined, gene and polymorphism information to be located in the domain are always updated. Recently next generation sequencing technologies is utilized for the polymorphism analyses of the HLA genomic region. Here, the latest HLA genome information and our experiences in the studies on the genomic diversity analyses of the HLA gene region and development of DNA typing method using the next generation sequencers are described.
