Abstract
Since the first pancreas transplantation (PTx) was introduced for severe diabetic patients in 1960s, over 40,000 cases have, so far, been performed worldwide. More than 80% of the patients underwent simultaneous pancreas and kidney transplantation (SPK). 237 PTxs [208; from DBD donors, 2; DCD donors, 27; LD donors] were performed from 2000 to 2014 in Japan. 5-year recipient survival was 95.8%. 5-year pancreas and kidney graft survivals were 70.4% and 89.2%, which were comparable to the data of UNOS. Also, 27 PTxs from LD donors showed the good results as well as PTxs from DBD donors. Although, 18 patients underwent islet transplantation using the pancreas from DCD donors in Japan, insulin independency was highly limited and the new protocol of isle transplantation using newly designed immunosuppressant has been started using DBD donors.
