1996 Volume 3 Issue 1 Pages 9-14
A serological subtype of HLA-A locus antigen, tentatively called HLA-A9HH, was identified in the Japanese population. A9HH showed short reaction patterns of a series to anti-A9 sera and reacted with some anti-A2 sera. Nucleotide sequence of full-length cDNA for A9HH was determined. The obtained sequence was compared with those of other A24 alleles reported to date, and it was revealed that this new sequence was identical with that of A* 2408 except at position 8 in exon 2. However, subsequently the nucleotide sequence of A* 2408 was revised by the original investigators and this revised sequence was found to be identical to that of A9HH. The nucleotide sequence of the allele for A9HH was identical to that of A* 2402 except for three nucleotides in exon 2. These three nucleotide changes cause three amino acid changes. Two of the three amino acids are shared by all the reported A2 alleles. These sequencing results of the allele for A9HH were consistent with the serological cross-reactivity of A9HH with some anti-A2 sera. The probable haplotypes carrying A9HH (A* 2408) are A9HH-Cw1-B54 and A9HH-Cw10-B35.
