高磁場MRIを用いた機能画像について

—中枢神経領域と腫瘍を中心に—

抄録

I introduced various kinds of functional imaging using a high magnetic field MR clinical instrument. Diffusion-weighted imaging and MR angiography are very useful for the diagnosis of transient ischemic attack(TIA), and MRI is an indispensable method to decide a therapeutic way for TIA. Furthermore, MRI and MRS spectroscopy can detect neuronal networks and neurotransmitters non-invasively, which are very useful to evaluate cerebral function and pathology of psychiatry diseases. In addition, angiogenesis and perfusion changes on tumors can be estimated using dynamic contrast methods by administration of Gd-DTPA. This information may be used to evaluate the molecular background and therapeutic perspective. MRI has been used for clinical diagnosis by visual estimation of morpholigical changes so far, but according to the increase of magnetic field and mechanical quality, it is now re-evaluated as an important modality to evaluate biological function quantitatively.