Research Papers
Chemical modification of imipramine and desipramine
2020 年 4 巻 1 号 p. 50-57
詳細
2020 年 4 巻 1 号 p. 50-57
Chemical modification of imipramine and desipramine, which have pharmaceutical applications such as an antidepressant was carried out. Dibromoimipramine and dibromodesipramine were prepared from imipramine hydrochloride and desipramine hydrochloride, respectively. Dibromodesipramine was reacted with di-tert-butyl dicarbonate to prepare N-Boc type compound. ESI-MS of the dibromides showed typical MS signals of dibromides. Polymerizations of the dibromides by the nickel-promoted coupling reaction afforded corresponding polymers. These results suggest that chemical modification of imipramine and desipramine expected to develop another functional material.
