Investigating oxidized lipids in an omics way: Oxidative lipidomics in biological applications using mass spectrometry

抄録

Oxidized lipids have been well known as potential markers of oxidative stress or other disorders in physiological/pathological processes, such as cardiovascular diseases, neurodegenerative diseases, and even some cancers. Lipidomic analysis is a modern and advanced approach to conducting informative elucidation for lipid molecules, which benefits biomarker hunting, clinical determination, and biological pathway exploration. In recent years, as mass spectrometry technology advances, lipidomics is extending the investigating range towards oxidized lipids, which is called oxidative lipidomics. This approach combines the complexity of the lipidome and focuses attention on oxidation. Because oxidized lipids are usually at low levels and artificial oxidation is undesired, oxidative lipidomics is more challenging than ordinary lipidomics, particularly in sample preparation, standards, and spectrum analysis. Nowadays, oxidative lipidomic analysis has been applied to biomedical science for various diseases in clinics and animal experiments on disease models. This review aims at the strategies and methods of oxidative lipidomics and the summary of current applications. The development of chromatographic-MS spectrometric technology is hopeful to allow a deeper and broader understanding of lipids and oxidation concerning human health.