Effects of Image Distortion Correction on Voxel-based Morphometry

Masami GOTO; Osamu ABE; Hiroyuki KABASAWA; Hidemasa TAKAO; Tosiaki MIYATI; Naoto HAYASHI; Tomomi KUROSU; Takeshi IWATSUBO; Fumio YAMASHITA; Hiroshi MATSUDA; Sachiko INANO; Harushi MORI; Akira KUNIMATSU; Shigeki AOKI; Kenji INO; Keiichi YANO; Kuni OHTOMO; Japanese Alzheimer's Disease Neuroimaging Initiative

doi:10.2463/mrms.11.27

Major Papers

Effects of Image Distortion Correction on Voxel-based Morphometry

Masami GOTO, Osamu ABE, Hiroyuki KABASAWA, Hidemasa TAKAO, Tosiaki MIYATI, Naoto HAYASHI, Tomomi KUROSU, Takeshi IWATSUBO, Fumio YAMASHITA, Hiroshi MATSUDA, Sachiko INANO, Harushi MORI, Akira KUNIMATSU, Shigeki AOKI, Kenji INO, Keiichi YANO, Kuni OHTOMO, Japanese Alzheimer's Disease Neuroimaging Initiative

Author information

Masami GOTO
Department of Radiological Technology, University of Tokyo Hospital
Graduate School of Medical Science, Kanazawa University
Osamu ABE
Department of Radiology, Nihon University School of Medicine
Hiroyuki KABASAWA
Japan Applied Science Laboratory, GE Healthcare
Hidemasa TAKAO
Department of Radiology, University of Tokyo Hospital
Tosiaki MIYATI
Graduate School of Medical Science, Kanazawa University
Naoto HAYASHI
Department of Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo Hospital
Tomomi KUROSU
Department of Radiological Technology, University of Tokyo Hospital
Takeshi IWATSUBO
Department of Neuropathology, University of Tokyo
Fumio YAMASHITA
Department of Radiology, National Center Hospital of Neurology and Psychiatry
Hiroshi MATSUDA
Department of Nuclear Medicine, Saitama Medical University International Medical Center
Sachiko INANO
Department of Radiology, University of Tokyo Hospital
Harushi MORI
Department of Radiology, University of Tokyo Hospital
Akira KUNIMATSU
Department of Radiology, University of Tokyo Hospital
Shigeki AOKI
Department of Radiology, Juntendo University
Kenji INO
Department of Radiological Technology, University of Tokyo Hospital
Keiichi YANO
Department of Radiological Technology, University of Tokyo Hospital
Kuni OHTOMO
Department of Radiology, University of Tokyo Hospital
Japanese Alzheimer's Disease Neuroimaging Initiative

Keywords: brain volumetry, distortion correction, gradient field nonlinearities, magnetic resonance imaging, voxel-based morphometry

JOURNAL OPEN ACCESS

2012 Volume 11 Issue 1 Pages 27-34

DOI https://doi.org/10.2463/mrms.11.27

Details

Abstract

Purpose: We aimed to show that correcting image distortion significantly affects brain volumetry using voxel-based morphometry (VBM) and to assess whether the processing of distortion correction reduces system dependency.
Materials and Methods: We obtained contiguous sagittal T₁-weighted images of the brain from 22 healthy participants using 1.5- and 3-tesla magnetic resonance (MR) scanners, preprocessed images using Statistical Parametric Mapping 5, and tested the relation between distortion correction and brain volume using VBM.
Results: Local brain volume significantly increased or decreased on corrected images compared with uncorrected images. In addition, the method used to correct image distortion for gradient nonlinearity produced fewer volumetric errors from MR system variation.
Conclusion: This is the first VBM study to show more precise volumetry using VBM with corrected images. These results indicate that multi-scanner or multi-site imaging trials require correction for distortion induced by gradient nonlinearity.

Corresponding author

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