Double-tuned Radiofrequency Coil for ¹⁹F and ¹H Imaging

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We developed a double-tuned radiofrequency (RF) coil using a novel circuit method to double tune for fluorine-19 (¹⁹F) and ¹H magnetic resonance imaging, whose frequencies are very close to each other. The RF coil consists of 3 parallel-connected series inductor capacitor circuits. A computer simulation for our double-tuned RF coil with a phantom demonstrated that the coil has tuned resonant frequency and high sensitivity for both ¹⁹F and ¹H. Drug distribution was visualized at 7 tesla using this RF coil and a rat administered perfluoro 15-crown-5-ether emulsion. The double-tune RF coil we developed may be a powerful tool for ¹⁹F and ¹H imaging.