Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan

Mitsuhiro Tozaki; Seigo Nakamura; Dai Kitagawa; Takuji Iwase; Rie Horii; Futoshi Akiyama; Masami Arai

doi:10.2463/mrms.cr.2016-0090

This article has now been updated. Please use the final version.

Ductal Carcinoma in situ Detected during Prospective MR Imaging Screening of a Woman with a BRCA2 Mutation: The First Case Report in Japan

Mitsuhiro Tozaki, Seigo Nakamura, Dai Kitagawa, Takuji Iwase, Rie Horii, Futoshi Akiyama, Masami Arai

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Keywords: hereditary breast and ovarian cancer syndrome, BRCA2, magnetic resonance imaging, ductal carcinoma in situ

JOURNAL OPEN ACCESS Advance online publication

Article ID: cr.2016-0090

DOI https://doi.org/10.2463/mrms.cr.2016-0090

The final version of this article is now available: Vol. 16 (2017), No. 3 pp. 265-269

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Abstract

The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. This case is significant and it verifies the importance of MRI screening in breast or ovarian cancer-free BRCA1/2 mutation carriers who do not exhibit positive mammographic or ultrasonographic findings.

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