Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Enrico Tedeschi; Sirio Cocozza; Pasquale Borrelli; Lorenzo Ugga; Vincenzo Brescia Morra; Giuseppe Palma

doi:10.2463/mrms.cr.2016-0137

This article has now been updated. Please use the final version.

Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure

Enrico Tedeschi, Sirio Cocozza, Pasquale Borrelli, Lorenzo Ugga, Vincenzo Brescia Morra, Giuseppe Palma

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Keywords: gadolinium, magnetic resonance imaging contrast media, dentate nucleus, multiple sclerosis, relaxometry

JOURNAL OPEN ACCESS Advance online publication

Article ID: cr.2016-0137

DOI https://doi.org/10.2463/mrms.cr.2016-0137

The final version of this article is now available: Vol. 17 (2018), No. 1 pp. 100-104

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Abstract

We report the assessment of Dentate Nuclei (DN) R1 (1/T₁) and R2* (1/R2*) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric magnetic resonance (MR) measurements within two years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.

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