抄録
Hydroxyapatite (Ca10 (PO4) 6 (OH) 2; HAp) and β-tricalcium phosphate (β-Ca3 (PO4) 2; β-TCP) are bio-compatible materials with bones and teeth. HAp is promising bone substitute materials for clinical applications because of chemical stability in vivo, while β-TCP has higher resorbability than HAp when the material is implanted in a bone defect. In the present study, HAp and β-TCP were soaked in the simulated body fluid, and then the reaction between the materials and the fluid was investigated in order to compare with the reaction in vivo. From the soaking test, carbonate hydroxyapatite was formed on the surface of HAp after 1 week, and then the amount of carbonate hydroxyapatite increased with increasing period of the soaking test. While β-TCP was not dissolved in the fluid, the carbonate hydroxyapatite was also formed on β-TCP after 12 weeks, and the amount of the precipitates on β-TCP was less than that on HAp. The reaction for HAp in vitro was similar to that in vivo, but the reaction for β-TCP in vitro was not similar to that in vivo.
