The extract of Talaromyces flavus IFM52668 showed the characteristic antifungal activity against Aspergillus fumigatus. In the course of a search for the active compounds, funicone, vermistatin, and a new funicone derivative, 9,14-epoxy-11-deoxyfunicone, were isolated along with emerin. The structure of 9,14-epoxy-11-deoxyfunicone was determined from the analysis of the spectroscopic investigation. The antifungal activity of the compounds was discussed.
2004 by Japanese Society of Mycotoxicology