Non-canonical function of tRNA synthetases from plants

Abstract

  Aminoacyl-tRNA synthetases (aaRSs) play a vital role in protein translation, establishing the genetic code by catalyzing an attachment of amino acids to their cognate tRNAs. Now, novel non-canonical functions of aaRSs have begun to emerge, uncovering numerous roles of aaRSs in higher eukaryotes, such as cancer signaling, immune response, and nutrition signaling. A recent study summarized in this report demonstrated a relationship between plant aaRS and a mycotoxin DON.