Some monoamine oxidase inhibitory components from Mycelia Sterilia derived from an Ascomycete, Gelasinospora pseudoreticulata

Abstract

Three new components, tentatively named GP-A, -B, and -C, with monoamine oxidase (MAO) inhibitory activity and a known anthraquinone chrysophanol were isolatedfrom Mycelia Sterilia derived from an Ascomycete, Gelasinospora pseudoreticulata.GP-A and -B, the main MAO inhibitory principles of this fungus, were deduced tobe 5-hydroxy-7-methoxy-4, 9-dioxonaphtho[2, 3-c]furan and l, 3-dihydro-5-hydroxy-7-methoxy-4, 9-dioxo-naphtho[2, 3-c]furan, respectively. The IC₅₀ values of GP-A, -B, and -C were evaluated against the MAO from mouse liver.