The effect of versicolorin A on electrical conductance in planar lipid bilayer membranes

Abstract

The effect of versicolorin A on ionic permeability in planar lipid bilayer membranes was studied by measuring current-changes at various conditions. Versicolorin A significantly elevated the conductance of lipid bilayer membranes. From an analysis of reversal potential, it was concluded that versicolorin A increased the bilayer conductance by facilitating proton permeability, suggesting that the conductance-increasing activity may contribute to the uncoupling effect of versicolorin A on mitochondrial respiration.