Abstract
Aflatoxins (AFs) are toxic and carcinogenic secondary metabolites produced by certain strains of Aspergillus flavus, A. parasiticus A. nomius and A. tamarii. In order to devise effective methods for preventing aflatoxin contamination of feed and food, elucidation of aflatoxin biosynthetic mechanism by fungi is important. I would like to overview recent topics relating aflatoxin biosynthesis, and then to introduce our recent results about vrdA gene coding versiconal hemiacetal acetate reductase involved in aflatoxin biosynthesis.