Abstract
Since many years ago “Shibu”, unripe persimmon's acrid juice old enough to be drink able, has privately been used as a remedy of hypertension and apoplexy among the people in Northern Japan, but it seems to me that there are neither exact clinical, nor precise experimental investigations. Suggested by it, I studied accurately on the clinical effect of “Shibu” for many patients suffering from essential hypertension.
1) “Shibu” shows an unquestionable depressor effect on the high blood pressure of hypertensive patient. It lowered not only the systolic blood pressure, but also the diastolic blood pressure.
2) Its side action is some stomach symptoms and obstipation probably caused by “Shibuol”, a tannin-like substance contained in the acrid juice. Therefore “Shibuol” was precipitated in the 0.5% gelatine solution, and the filtrate also showed the likewise depressor effect without any unpleasant side action.
3) “Shibu” has no harmful influence upon the blood corpuscles, the function of heart, kidney and liver.
4) It must be most useful as an adjunct reinforcing the curing action of other drugs against hypertension.
