The circulatory dynamics were serially examined in the hypertensive cases who were medicated for a long term with several depressant drugs. 1. The blood pressure lowers in the initial stage of the Rauwolfia serpentina application, but the peripheral resistance does not decrease. The depression at this term is due to mainly the reduction of cardiac output. Such a hemodynamic state is not favourable. By means of further medication, the blood pressure tends rather to elevate to some extent, but remains under the control level. The total peripheral resistance significantly decreases, and approaches to normal range. This slight change of initially depressed blood pressure is due to the moderate increase of cardiac output. So-called dynamical mean pressure is kept on lower level. 2. By the chronic use of 1-Hydrazinophthalazine (Apresoline “Ciba”) the cardiac rates increase slightly, but both stroke and minute volume decrease markedly. The agent also reduces elasticity modulus and total peripheral resistance. From theoretical viewpoint such a hemodynamic state is favourable. 3. The circulatory dynamics were examined in the hypertensive cases who were medicated parenterally with ganglionic blocking agents. The decrease of cardiac output and the increase of peripheral resistance are observed during depression; such a hemodynamic condition is not favourable. But these results do not necessarily mean that the ganglionic blocking drugs are not suitable for the therapy of the high blood pressure, because these results were obtained merely by the acute use, so the increase of peripheral resistance is considered to be due to the homeostasis against the abrupt hypotension which is brought by the medication of this sort of agents.
K reaction, Costa's, Darányi's and cadmium reaction tests were applied to persons in normal health, cured of presently suffering from pulmonary tuberculosis, and their values in practical use studied in comparison. The following results were obtained. 1) K reaction showed higher rates of negative results than the other 3 methods, when applied to healthy persons and those cured of tuberculosis. 2) In pulmonary tuberculosis patients, K reaction showed higher rates of positive reaction than the other methods. 3) K reaction test is simpler in operation and more welldefind in estimation of the results than the other methods. From these results, we are led to conclude that K reaction test is better adapted for practical use than Costa's, Daranyi's and cadmium reaction tests.
Since many years ago “Shibu”, unripe persimmon's acrid juice old enough to be drink able, has privately been used as a remedy of hypertension and apoplexy among the people in Northern Japan, but it seems to me that there are neither exact clinical, nor precise experimental investigations. Suggested by it, I studied accurately on the clinical effect of “Shibu” for many patients suffering from essential hypertension. 1) “Shibu” shows an unquestionable depressor effect on the high blood pressure of hypertensive patient. It lowered not only the systolic blood pressure, but also the diastolic blood pressure. 2) Its side action is some stomach symptoms and obstipation probably caused by “Shibuol”, a tannin-like substance contained in the acrid juice. Therefore “Shibuol” was precipitated in the 0.5% gelatine solution, and the filtrate also showed the likewise depressor effect without any unpleasant side action. 3) “Shibu” has no harmful influence upon the blood corpuscles, the function of heart, kidney and liver. 4) It must be most useful as an adjunct reinforcing the curing action of other drugs against hypertension.
On high efficient Cation Exchange Resins, AmRIR IR 120 and AmR IRC 50 and Anion Exchange Resin AmRIR IR 4 which are now most widely used in Japan. I conducted experiments in vitro and in vivo to see if they will absorb amino-acid, the most important nutritive substance for a human body, when they are taken or whether or not they will be hindered from absorbed it. As a result of the experiments, I knew part of basic amino-acids are absorbed and excreted by Cation Exchange Resins. Furthermore administering H-type and NH4-type of AmRIR 120 and AmR IRC 50 to rats, I observed these facts: 1) The rat's weight did not undergo a remarkable change and the urine increased in quantity. 2) The excretion of Na and K in the urine remarkably increased, while that of Na and K in the feces decreased. 3) The sum of excretion of Na and K in the feces and urine showed an increase in proportion to its contrast. 4) The excretion of N decreased in H-type and increased in NH4-type.