Abstract
It is not yet clear whether the fever with inflammation is induced by the bacterial pyrogen itself, or by the endogenous pyrogenic substances which are secondarily yielded from tissue or cells injured by the micro-organism. And non-infectious fever in various conditions such as hemolysis, infarction, bleeding, malignant neoplasma and non-infectious inflammation, may be induced by some endogenous pyrogenic substances released from injured cells or tissues.
As Bennett and Beeson indicated, it is possible that bacterial contamination disturbs the results of the studies on endogenous pyrogenic substances. I have studied systematically on this endogenous fever, avoiding very carefully bacterial contamination by aseptic procedures.
The results are summerized as follows;
1) Menkin's pyrexin fraction extracted from the exudates of aseptic pleurisy in dogs caused by turpentine oil, failed to elevate temperature of rabbits except one sample. However, there was more pyrogenic activity in euglobulin and pseudoglobulin fractions extracted from the same exudates.
2) About a half of samples of desoxyribonucleo-protein, desoxyribonucleic acid, protein parts of this nucleoprotein, and those treated by trypsin or streptodornase, extracted from rabbit organs (liver, spleen, kidney, heart muscles and lymphatic nodes) and from the exudate of experimental aseptic pleurisy in dog, increased body temperature of rabbits.
3) The majority of samples of mucoprotein (Winzler) extracted from the sera or exudates of the dogs with experimental pleurisy increased body temperature of rabbits.
4) It is possible that the protein or polypeptide, especially combined with nucleic acid or polysaccharides, is liberated from the inflammatory tissue or cells and causes endogenous fever in the inflammation.
