Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans
Kanako SHITOMIHirofumi MIYAJISaori MIYATAErika NISHIDAKayoko MAYUMITsutomu SUGAYAHideya KAWASAKI
Author information
JOURNALS FREE ACCESS

2019 Volume 11 Issue 1 Pages 21-28

Details
Abstract

Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective antibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag∼75) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate.

Information related to the author
© 2019 Nano Biomedical Society
Previous article Next article
feedback
Top