Nano Biomedicine
Online ISSN : 2185-4734
Print ISSN : 1883-5198
ISSN-L : 1883-5198
ORIGINAL ARTICLES
Influence of Fluoride-corroded Ti-6Al-4V Alloy on Cell differentiation and Cell Viability
Koichi IMAIYoshiya HASHIMOTOMari AKIYAMATsubasa SHIRAIMariko NAKAITadashi YOKOYAMATakamitsu YOSHIDAMasayuki ZENNYUKousuke KASHIWAGIRyo NISHIKIORITakahiro SHUTOXiaoyu HANKazuyo YAMAMOTO
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2019 Volume 11 Issue 1 Pages 29-36

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Abstract

Dental metals have toxic effects on human development, including the high toxicity of the constituent element vanadium of the standard product ASTM F136, i.e., the medical titanium material of the Ti-6Al-4V alloy used in dental implants for its mechanical strength due to the use of a large amount of pure Ti. In addition, the corrosion of pure Ti and Ti alloy implants due to fluorides in the oral cavity is a problem. Elution of the constituent element vanadium due to corrosion may have toxic effects on development. Therefore, each element composing Ti-6Al-4V was examined in an in vitro embryotoxicity test by the Embryonic Stem Cell Test (EST) protocol. As a result, only vanadium had a risk of embryotoxicity. In addition, the Ti-6Al-4V alloy was corroded with hydrofluoric acid to examine its effects on the differentiation of mouse-derived ES and iPS cells, and was found to affect the differentiation of both cell types.

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© 2019 Nano Biomedical Society
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