Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial                    Activity against Streptococcus mutans

Kanako SHITOMI; Hirofumi MIYAJI; Saori MIYATA; Erika NISHIDA; Kayoko MAYUMI; Tsutomu SUGAYA; Hideya KAWASAKI

doi:10.11344/nano.11.21

ORIGINAL ARTICLES

Human Dentin Coated with Silver Nanoclusters Exhibits Antibacterial Activity against Streptococcus mutans

Kanako SHITOMI, Hirofumi MIYAJI, Saori MIYATA, Erika NISHIDA, Kayoko MAYUMI, Tsutomu SUGAYA, Hideya KAWASAKI

著者情報

Kanako SHITOMI
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Hirofumi MIYAJI
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Saori MIYATA
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Erika NISHIDA
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Kayoko MAYUMI
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Tsutomu SUGAYA
Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
Hideya KAWASAKI
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

キーワード: antibacterial effect, human dentin, silver nanoclusters (AgNCs), streptococcus mutans

ジャーナルフリー

2019 年 11 巻 1 号 p. 21-28

DOI https://doi.org/10.11344/nano.11.21

詳細

抄録

Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective antibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag_∼75) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）