Cell Viability by Photo Irradiation with a Medium Containing Both                    Bis-GMA and Camphorquinone (CQ)

Tsubasa SHIRAI; Tan CHENG; Yuzhu SUN; Yufan WU; Ye ZHANG; Tetsuya HIRATA; Yoshiya HASHIMOTO; Koichi IMAI

doi:10.11344/nano.13.8

ORIGINAL ARTICLES

Cell Viability by Photo Irradiation with a Medium Containing Both Bis-GMA and Camphorquinone (CQ)

Tsubasa SHIRAI, Tan CHENG, Yuzhu SUN, Yufan WU, Ye ZHANG, Tetsuya HIRATA, Yoshiya HASHIMOTO, Koichi IMAI

Author information

Tsubasa SHIRAI
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Tan CHENG
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Yuzhu SUN
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Yufan WU
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Ye ZHANG
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Tetsuya HIRATA
Div. of Oral Maxilofacial Regeneration, Faculty of Dentistry, Osaka University, Osaka, Japan
Yoshiya HASHIMOTO
Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
Koichi IMAI
Department of Tissue Engineering, School of Dentistry, Osaka Dental University, Osaka, Japan
School of Health Sciences, Osaka Dental University, Osaka, Japan

Keywords: cell viability, Bis-GMA, camphorquinon, CQ, light-cured composite resin

JOURNAL OPEN ACCESS

2021 Volume 13 Issue 1 Pages 8-12

DOI https://doi.org/10.11344/nano.13.8

Details

Abstract

Little is known about the influence of the phototoxicity of dental materials. Light-cured composite resin is polymerized by intense light irradiation in the oral cavity, although it is temporary. There has been no report on the biological influence of intense light irradiation on oral cavity tissue. We previously confirmed that camphorquinone (CQ) contained in light-cured composite resin for dental use as a photosensitizer decreased the cell viability in a light-irradiated group compared with that in a non-irradiated group within a concentration range from 0.313 to 2.5 mg/mL using 3T3 cells specified in the OECD phototoxicity guidelines. In this study, we investigated the influence of light irradiation in actual light-cured composite resin mixed with Bis-GMA contained as a base monomer, not the influence of CQ alone, on the influence of light irradiation on cell viability. It was confirmed that similarly to CQ alone, the cell viability decreased in the state mixed with Bis-GMA.

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